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PIK4CA Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; plasma membrane
Molecular Function: 1-phosphatidylinositol 4-kinase activity; cadherin binding; kinase activity; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; phosphorylation; viral replication complex formation and maintenance
Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis
Reference #:  P42356 (UniProtKB)
Alt. Names/Synonyms: FLJ16556; phosphatidylinositol 4-kinase 230; Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase alpha; PI4K-alpha; pi4K230; PI4KA; PIK4; PIK4CA; PtdIns-4-kinase alpha
Gene Symbols: PI4KA
Molecular weight: 236,830 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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