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Yes a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 18p11.32
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; plasma membrane
Molecular Function: enzyme binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: cell differentiation; cell migration; ephrin receptor signaling pathway; innate immune response; leukocyte migration; protein modification process; regulation of cell proliferation; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P07947 (UniProtKB)
Alt. Names/Synonyms: c-yes; cellular yes-1 protein; HsT441; p61-Yes; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes-1 homolog 1; Yamaguchi sarcoma oncogene; YES; YES1
Gene Symbols: YES1
Molecular weight: 60,801 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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