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SNIP Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: actin cytoskeleton; axon; cytoplasm; dendrite; focal adhesion; postsynaptic density; synapse
Molecular Function: protein binding; protein kinase binding
Biological Process: regulation of cell migration
Reference #:  Q9C0H9 (UniProtKB)
Alt. Names/Synonyms: KIAA1684; p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein; SNAP25-interacting protein; SNIP; SRC kinase signaling inhibitor 1; SRCIN1; SRCN1
Gene Symbols: SRCIN1
Molecular weight: 112,453 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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