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ERK2 a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 22q11.22
Cellular Component: caveola; cytoplasm; cytoskeleton; cytosol; early endosome; extracellular region; focal adhesion; Golgi apparatus; late endosome; mitochondrion; nucleoplasm; nucleus; plasma membrane
Molecular Function: identical protein binding; kinase activity; MAP kinase activity; phosphatase binding; protein binding; protein serine/threonine kinase activity; RNA polymerase subunit kinase activity
Biological Process: activation of MAPK activity; axon guidance; cellular response to amino acid starvation; chemotaxis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; neutrophil degranulation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; platelet activation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; regulation of cytoskeleton organization and biogenesis; regulation of phosphoinositide 3-kinase cascade; regulation of protein stability; regulation of stress-activated MAPK cascade; regulation of transcription factor activity; response to nicotine; response to stress; signal transduction; stress-activated MAPK cascade; synaptic transmission
Reference #:  P28482 (UniProtKB)
Alt. Names/Synonyms: ERK; ERK-2; ERK2; ERT1; Extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; MAPK1; MAPK2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2; protein tyrosine kinase ERK2
Gene Symbols: MAPK1
Molecular weight: 41,390 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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