Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
ArgBP2 iso2

ArgBP2 iso2 Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8|8 B1.1
Cellular Component: cell soma; dendrite; plasma membrane; postsynaptic density
Molecular Function: protein domain specific binding; RNA binding
Biological Process: Notch signaling pathway
Reference #:  Q3UTJ2-2 (UniProtKB)
Alt. Names/Synonyms: 2010203O03Rik; 9430041O17Rik; A530071H08; Arg/Abl-interacting protein 2; Arg/Abl-interacting protein ArgBP2; ArgBP2; Kiaa0777; mKIAA0777; sorbin and SH3 domain containing 2; Sorbin and SH3 domain-containing protein 2; Sorbs2; SRBS2
Gene Symbols: Sorbs2
Molecular weight: 145,012 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
Select Structure to View Below

ArgBP2 iso2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein