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Protein Page:
HER3

Overview
HER3 a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral component of plasma membrane; intracellular; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; neuregulin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor activity; ubiquitin protein ligase binding
Biological Process: cranial nerve development; endocardial cushion development; ERBB2 signaling pathway; heart development; MAPK cascade; negative regulation of cell adhesion; negative regulation of ERBB signaling pathway; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol phosphorylation; phosphoinositide 3-kinase cascade; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; regulation of cell motility; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Disease: Lethal Congenital Contracture Syndrome 2
Reference #:  P21860 (UniProtKB)
Alt. Names/Synonyms: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: ERBB3
Molecular weight: 148,098 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HER3

Protein Structure Not Found.
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