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LIMK2 a TKL kinase of the LISK family that regulates actin dynamics. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. Phosphorylates cofilin, inhibiting its actin-depolymerizing activity. May contributes to Rho-induced reorganization of the actin cytoskeleton. Two alternative splice variants have been identified. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; protein serine/threonine kinase activity; signal transducer activity
Biological Process: phosphorylation
Reference #:  P53671 (UniProtKB)
Alt. Names/Synonyms: LIM domain kinase 2; LIMK-2; LIMK2
Gene Symbols: LIMK2
Molecular weight: 72,232 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
CST Pathways:  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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