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Fes a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene. Note: This description may include information from UniProtKB.
Protein type: EC; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tumor suppressor
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; microtubule cytoskeleton
Molecular Function: ATP binding; microtubule binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol binding; protein binding; protein tyrosine kinase activity
Biological Process: cell migration; cell proliferation; centrosome cycle; chemotaxis; epidermal growth factor receptor signaling pathway; innate immune response; microtubule bundle formation; multicellular organism development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of microtubule polymerization; positive regulation of myeloid cell differentiation; positive regulation of neuron projection development; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of cell motility; regulation of cell proliferation; regulation of cell shape; regulation of mast cell degranulation
Reference #:  P07332 (UniProtKB)
Alt. Names/Synonyms: c-fes/fps protein; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; FES; FPS; Oncogene FES, feline sarcoma virus; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase Fes/Fps
Gene Symbols: FES
Molecular weight: 93,497 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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