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DNAJA3 Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: actin filament; extrinsic to plasma membrane; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function: protein binding
Biological Process: mitochondrion organization and biogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q96EY1 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog
Gene Symbols: DNAJA3
Molecular weight: 52,489 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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