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PRMT5 an ubiquitous enzyme with protein methyltransferase activity. Methylates specific arginine residues in the transcription elongation factor SPT5, and the small nuclear ribonucleoproteins SNRPD1 and SNRPD3. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SPT5 transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Component of the methylosome, a 20S complex that includes ICLN, SKB1 and WDR77. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SPT5. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Methyltransferase; Methyltransferase, protein arginine; RNA processing
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone methyltransferase complex; nucleoplasm; nucleus
Molecular Function: histone-arginine N-methyltransferase activity; methyl-CpG binding; methyltransferase activity; protein binding; protein heterodimerization activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein binding; transcription corepressor activity
Biological Process: cell proliferation; circadian regulation of gene expression; endothelial cell activation; peptidyl-arginine methylation; peptidyl-arginine N-methylation; regulation of mitosis; regulation of transcription, DNA-dependent; spliceosomal snRNP biogenesis; transcription termination
Reference #:  O14744 (UniProtKB)
Alt. Names/Synonyms: 72 kDa ICln-binding protein; ANM5; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; HRMT1L5; IBP72; Jak-binding protein 1; JBP1; PRMT5; protein arginine methyltransferase 5; Protein arginine N-methyltransferase 5; Shk1 kinase-binding protein 1 homolog; SKB1; SKB1 homolog; SKB1Hs
Gene Symbols: PRMT5
Molecular weight: 72,684 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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