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Wee1 a protein kinase of the WEE family. A nuclear protein which catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); WEE family
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: nucleolus; nucleoplasm; nucleus
Molecular Function: kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cell cycle
Reference #:  P30291 (UniProtKB)
Alt. Names/Synonyms: DKFZp686I18166; FLJ16446; WEE1; WEE1 G2 checkpoint kinase; Wee1-like protein kinase; WEE1A; Wee1A kinase; WEE1hu
Gene Symbols: WEE1
Molecular weight: 71,597 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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