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PRP4 a kinase of the DYRK family associated with the spliceosome and the kinetochore. It binds pre-mRNA splicing factors SFRS8, PRP6 and pinin. It is an essential kinase that associates with both the U5 snRNP and the N-CoR deacetylase complexes. It may help coordinate pre-mRNA splicing with chromatin remodeling and transcriptional regulation. PRP4 has recently been shown to be a kinetochore component that is necessary to establish a functional spindle assembly checkpoint, and is necessary for recruitment or maintenance of the checkpoint proteins RPS27, MAD1, and MAD2 at the kinetochores. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; EC; Kinase, protein; PRP4 subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome
Chromosomal Location of Human Ortholog: 6p25.2
Cellular Component: nuclear speck
Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein kinase activity; RNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q13523 (UniProtKB)
Alt. Names/Synonyms: dJ1013A10.1; dJ1013A10.1 (PRP4 protein kinase homolog); KIAA0536; PR4H; PRP4; PRP4 kinase; PRP4 pre-mRNA processing factor 4 homolog B (yeast); PRP4 pre-mRNA-processing factor 4 homolog; PRP4B; PRP4H; PRP4K; PRPF4B; Serine/threonine-protein kinase PRP4 homolog; serine/threonine-protein kinase PRP4K
Gene Symbols: PRPF4B
Molecular weight: 116,987 Da
Basal Isoelectric point: 10.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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