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CARD11 a CARD (caspase recruitment domain) protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. MAGUK proteins function as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. Contains an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal region containing a PDZ, an SH3, and a GUK. Its CARD domain associates with the CARD domain of BCL10. BCL10 activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Apparently activates NF-kappaB and induce the phosphorylation of BCL10. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p22.2
Cellular Component: cytoplasm; cytosol; lipid raft; plasma membrane; T cell receptor complex
Molecular Function: CARD domain binding; protein binding
Biological Process: activation of NF-kappaB transcription factor; positive regulation of cytokine production; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway
Disease: B-cell Expansion With Nfkb And T-cell Anergy; Immunodeficiency 11; Persistent Polyclonal B-cell Lymphocytosis
Reference #:  Q9BXL7 (UniProtKB)
Alt. Names/Synonyms: bcl10-interacting maguk protein 3; BIMP3; CAR11; CARD-containing MAGUK protein 1; card-maguk protein 1; CARD11; Carma 1; CARMA1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Symbols: CARD11
Molecular weight: 133,284 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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