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VRK1 Serine/threonine kinase that phosphorylates Thr-18 of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component: cytosol; Golgi stack; nucleolus; nucleoplasm; nucleus
Molecular Function: histone serine kinase activity (H3-S10 specific); nucleosomal histone binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape
Disease: Pontocerebellar Hypoplasia, Type 1a
Reference #:  Q99986 (UniProtKB)
Alt. Names/Synonyms: MGC117401; MGC138280; MGC142070; PCH1; Serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; VRK1
Gene Symbols: VRK1
Molecular weight: 45,476 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
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