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SHMT1 Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; Energy Metabolism - methane; Lyase; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytosol; nucleus
Molecular Function: glycine hydroxymethyltransferase activity; identical protein binding; mRNA 5'-UTR binding; protein binding; protein homodimerization activity; pyridoxal phosphate binding; translation repressor activity, nucleic acid binding
Biological Process: carnitine biosynthetic process; folic acid metabolic process; glycine metabolic process; L-serine catabolic process; L-serine metabolic process; negative regulation of translation; protein homotetramerization; protein tetramerization; purine base biosynthetic process; tetrahydrofolate metabolic process
Reference #:  P34896 (UniProtKB)
Alt. Names/Synonyms: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; GLYC; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; SHMT1
Gene Symbols: SHMT1
Molecular weight: 53,083 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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