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RPT6 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; membrane; nucleoplasm; nucleus; proteasome complex
Molecular Function: ATPase activity; protein binding; TATA-binding protein binding; thyrotropin-releasing hormone receptor binding; transcription factor binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ER-associated protein catabolic process; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P62195 (UniProtKB)
Alt. Names/Synonyms: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; MSUG1 protein; p45; p45/SUG; proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; PRS8; PSMC5; RPT6; S8; SUG-1; SUG1; Tat-binding protein homolog 10; TBP10; Thyroid hormone receptor-interacting protein 1; thyroid receptor interactor 1; TRIP1
Gene Symbols: PSMC5
Molecular weight: 45,626 Da
Basal Isoelectric point: 7.11  Predict pI for various phosphorylation states
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