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EIF4A1 ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69. Helicase activity and function in translation are inhibited by interaction with PDCD4. Belongs to the DEAD box helicase family. eIF4A subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; extracellular matrix; membrane; nucleus
Molecular Function: ATP-dependent RNA helicase activity; double-stranded RNA binding; helicase activity; mRNA binding; protein binding; RNA binding; RNA cap binding; translation factor activity, nucleic acid binding
Biological Process: poly(A) tail shortening; regulation of gene expression; RNA secondary structure unwinding; translational initiation
Reference #:  P60842 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase eIF4A-1; DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I; EIF4A1; Eukaryotic initiation factor 4A-I; eukaryotic initiation factor 4AI; eukaryotic translation initiation factor 4A, isoform 1; eukaryotic translation initiation factor 4A1; IF4A1
Gene Symbols: EIF4A1
Molecular weight: 46,154 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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