Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

DDX6 an oncogenic ATP-dependent helicase of the DEAD box family. Interacts with argonaute proteins, Ago1 and Ago2, and is a general repressor of translation in human cells by miRNA-induced gene silencing. In the process of mRNA degradation, may play a role in mRNA decapping. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Oncoprotein; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleus; stress granule
Molecular Function: ATP-dependent RNA helicase activity; cadherin binding; helicase activity; protein binding; protein domain specific binding; RNA binding; RNA helicase activity
Biological Process: cytoplasmic mRNA processing body assembly; regulation of translation; RNA secondary structure unwinding; viral RNA genome packaging
Reference #:  P26196 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase p54; DDX6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD box protein 6; DEAD box-6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK
Gene Symbols: DDX6
Molecular weight: 54,417 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene