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NAA10 In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; cytosol; intracellular; membrane; nucleolus; nucleus
Molecular Function: acetyltransferase activity; N-acetyltransferase activity; peptide alpha-N-acetyltransferase activity; protein binding; ribosome binding
Biological Process: DNA packaging; internal protein amino acid acetylation; N-terminal peptidyl-glutamic acid acetylation; N-terminal peptidyl-serine acetylation; N-terminal protein amino acid acetylation; protein amino acid acetylation
Disease: Microphthalmia, Syndromic 1; Ogden Syndrome
Reference #:  P41227 (UniProtKB)
Alt. Names/Synonyms: ARD1; ARD1 homolog A, N-acetyltransferase; ARD1 homolog, N-acetyltransferase; ARD1A; DXS707; MGC71248; N(alpha)-acetyltransferase 10, NatA catalytic subunit; N-acetyltransferase ARD1, human homolog of; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; NAA10; OTTHUMP00000026001; OTTHUMP00000026002; OTTHUMP00000064808; OTTHUMP00000064809; OTTHUMP00000180622; OTTHUMP00000180623; TE2
Gene Symbols: NAA10
Molecular weight: 26,459 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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