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DCK Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 5|5 E1
Cellular Component: cytosol; nucleus
Molecular Function: ATP binding; deoxycytidine kinase activity; drug binding; magnesium ion binding; nucleoside kinase activity; protein homodimerization activity; pyrimidine deoxyribonucleoside binding
Biological Process: deoxycytidine metabolic process; drug metabolic process; pyrimidine nucleotide metabolic process
Reference #:  P43346 (UniProtKB)
Alt. Names/Synonyms: Dck; Deoxycytidine kinase; OTTMUSP00000030586
Gene Symbols: Dck
Molecular weight: 30,367 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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