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STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; protein phosphatase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; response to cytokine stimulus; signal transduction; T-helper 1 cell lineage commitment
Reference #:  NP_001037715 (RefSeq)
Alt. Names/Synonyms: signal transducer and activator of transcription 6; STAT6
Gene Symbols: Stat6
Molecular weight: 93,870 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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