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IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB.
Protein type: IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  O43187 (UniProtKB)
Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550
Gene Symbols: IRAK2
Molecular weight: 69,433 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
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