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IRF5 Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q32.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: positive regulation of apoptosis; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription from RNA polymerase II promoter; response to muramyl dipeptide; response to peptidoglycan
Disease: Inflammatory Bowel Disease 14; Systemic Lupus Erythematosus, Susceptibility To, 10
Reference #:  Q13568 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 5; IRF-5; IRF5; SLEB10
Gene Symbols: IRF5
Molecular weight: 56,044 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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