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CTMP According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. Interacts with AKT1. Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytosol; mitochondrial matrix; mitochondrion; plasma membrane
Molecular Function: acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity
Biological Process: acyl-CoA metabolic process; fatty acid metabolic process; protein kinase B signaling cascade
Reference #:  Q5T1C6 (UniProtKB)
Alt. Names/Synonyms: C-terminal modulator protein; Carboxyl-terminal modulator protein; CTMP; MGC29636; THEM4; Thioesterase superfamily member 4
Gene Symbols: THEM4
Molecular weight: 27,130 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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