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CDC42 a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4 D3|4 69.83 cM
Cellular Component: apical part of cell; cell projection; cytoplasm; cytosol; Golgi membrane; intercellular junction; myelin sheath; plasma membrane; secretory granule
Molecular Function: GTP binding; GTP-dependent protein binding; GTPase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase binding; Rho GDP-dissociation inhibitor binding
Biological Process: actin filament bundle formation; actin filament organization; Cdc42 protein signal transduction; cell-cell adhesion; endocytosis; endosome transport; epidermis morphogenesis; establishment and/or maintenance of apical/basal cell polarity; establishment and/or maintenance of cell polarity; establishment of Golgi localization; filopodium formation; Golgi organization and biogenesis; hair follicle morphogenesis; heart contraction; keratinization; multicellular organism growth; neuron fate determination; nuclear migration; nucleus localization; positive regulation of catalytic activity; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of neuron apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of synapse structural plasticity; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein kinase activity; regulation of protein metabolic process; regulation of protein stability; Rho protein signal transduction; sprouting angiogenesis; Wnt receptor signaling pathway through beta-catenin
Reference #:  P60766 (UniProtKB)
Alt. Names/Synonyms: AI747189; AU018915; Cdc42; Cell division control protein 42 homolog; cell division cycle 42 homolog (S. cerevisiae); G25K GTP-binding protein; OTTMUSP00000010388
Gene Symbols: Cdc42
Molecular weight: 21,259 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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