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CDC27 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with RB. Interacts with FAM168B/MANI. Belongs to the APC3/CDC27 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: anaphase-promoting complex; centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; spindle; spindle microtubule
Molecular Function: protein binding; protein phosphatase binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; mitotic metaphase/anaphase transition; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Reference #:  P30260 (UniProtKB)
Alt. Names/Synonyms: ANAPC3; anaphase promoting complex subunit 3; anaphase-promoting complex, protein 3; APC3; CDC27; CDC27 homolog; CDC27Hs; cell division cycle 27 homolog (S. cerevisiae); cell division cycle protein 27; Cell division cycle protein 27 homolog; D0S1430E; D17S978E; H-NUC; HNUC; nuc2 homolog
Gene Symbols: CDC27
Molecular weight: 91,867 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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