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CD38 Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC; EC; Hydrolase; Lyase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p15.32
Cellular Component: cell surface; integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function: NAD(P)+ nucleosidase activity; NAD+ nucleosidase activity; phosphorus-oxygen lyase activity; transferase activity
Biological Process: B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; female pregnancy; NAD metabolic process; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of insulin secretion; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; response to drug; response to estradiol; response to hydroperoxide; response to hypoxia; response to progesterone; response to retinoic acid; signal transduction
Reference #:  P28907 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; cADPr hydrolase 1; CD38; CD38 antigen (p45); CD38 molecule; Cyclic ADP-ribose hydrolase 1; T10
Gene Symbols: CD38
Molecular weight: 34,328 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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