Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 184.108.40.206; EC 220.127.116.11; Hydrolase; Lyase; Membrane protein, integral
Biological Process: B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; female pregnancy; NAD metabolic process; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of insulin secretion; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; response to drug; response to estradiol; response to hydroperoxide; response to hypoxia; response to progesterone; response to retinoic acid; signal transduction