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GZMA This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: immunological synapse; nucleus
Molecular Function: protein binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: apoptosis; immune response; negative regulation of DNA binding; negative regulation of endodeoxyribonuclease activity; negative regulation of oxidoreductase activity; positive regulation of apoptosis; proteolysis involved in cellular protein catabolic process
Reference #:  P12544 (UniProtKB)
Alt. Names/Synonyms: CTL tryptase; CTLA3; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; GRAA; Granzyme A; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); Granzyme-1; GZMA; H factor; Hanukah factor serine protease); Hanukkah factor; HF; HFSP
Gene Symbols: GZMA
Molecular weight: 28,999 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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