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STLK3 May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; FRAY subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: cytoplasm; cytosol; extrinsic to membrane; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway
Reference #:  Q9UEW8 (UniProtKB)
Alt. Names/Synonyms: DCHT; DKFZp686K05124; PASK; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; SPAK; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STK39
Gene Symbols: STK39
Molecular weight: 59,474 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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