May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; FRAY subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Molecular Function: kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; stress-activated protein kinase signaling pathway