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MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of Human Ortholog: Xp22.12
Cellular Component: cytoplasm; endoplasmic reticulum membrane; Golgi membrane
Molecular Function: metalloendopeptidase activity
Biological Process: membrane protein intracellular domain proteolysis; positive regulation of transcription factor activity; regulation of cholesterol biosynthetic process; regulation of lipoprotein lipase activity; unfolded protein response
Disease: Ifap Syndrome With Or Without Bresheck Syndrome; Keratosis Follicularis Spinulosa Decalvans, X-linked; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked
Reference #:  O43462 (UniProtKB)
Alt. Names/Synonyms: Endopeptidase S2P; FLJ32174; IFAP; MBTP2; MBTPS2; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; Membrane-bound transcription factor site-2 protease; S2P; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease
Gene Symbols: MBTPS2
Molecular weight: 57,444 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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