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SMPD2 Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. Belongs to the neutral sphingomyelinase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: glycosphingolipid metabolic process; sphingomyelin metabolic process
Reference #:  O60906 (UniProtKB)
Alt. Names/Synonyms: ISC1; Lyso-PAF-PLC; Lyso-platelet-activating factor-phospholipase C; N-SMase; Neutral sphingomyelinase; NSMA; nSMase; NSMASE1; SMPD2; Sphingomyelin phosphodiesterase 2; sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene Symbols: SMPD2
Molecular weight: 47,646 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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