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RHEB Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Ubiquitous. Highest levels observed in skeletal and cardiac muscle. Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2. Belongs to the small GTPase superfamily. Rheb family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rheb
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: lysosomal membrane; membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; magnesium ion binding
Biological Process: cell cycle arrest; positive regulation of TOR signaling pathway; regulation of macroautophagy
Reference #:  Q15382 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein Rheb; MGC111559; Ras homolog enriched in brain; Ras homolog enriched in brain 2; RHEB; RHEB2
Gene Symbols: RHEB
Molecular weight: 20,497 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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