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SGK2 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); SGK family
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cytosol; intracellular; nucleoplasm
Molecular Function: calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein serine/threonine kinase activity; sodium channel regulator activity
Biological Process: peptidyl-serine phosphorylation; positive regulation of transporter activity; regulation of apoptosis; regulation of cell growth; regulation of cell proliferation; response to oxidative stress
Reference #:  Q9HBY8 (UniProtKB)
Alt. Names/Synonyms: dJ138B7.2; H-SGK2; Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2; SGK2
Gene Symbols: SGK2
Molecular weight: 47,604 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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