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ROCK2 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1. Activated by RHOA binding. Inhibited by Y-27632. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); ROCK subfamily
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: centrosome; cytosol
Molecular Function: protein binding; protein serine/threonine kinase activity; RNA binding
Biological Process: centrosome duplication; cortical actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; negative regulation of angiogenesis; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell adhesion; regulation of circadian rhythm; regulation of focal adhesion formation; regulation of keratinocyte differentiation; regulation of stress fiber formation; smooth muscle contraction; vascular endothelial growth factor receptor signaling pathway
Reference #:  O75116 (UniProtKB)
Alt. Names/Synonyms: KIAA0619; p164 ROCK-2; Rho kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; ROCK2
Gene Symbols: ROCK2
Molecular weight: 160,900 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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