a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; EC 188.8.131.52; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle
Molecular Function: CARD domain binding; identical protein binding; LIM domain binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; adaptive immune response; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; JNK cascade; MAPKKK cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; protein deubiquitination; signal transduction; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway