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TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: cell surface; external side of plasma membrane; extracellular space; integral to plasma membrane; receptor complex
Molecular Function: coreceptor activity; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; punt binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cell growth; cell migration; epithelial to mesenchymal transition; heart morphogenesis; immune response; liver development; negative regulation of cell motility; negative regulation of epithelial cell proliferation; palate development; positive regulation of cardiac muscle cell proliferation; regulation of JNK cascade; response to follicle-stimulating hormone stimulus; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
Reference #:  Q03167 (UniProtKB)
Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: TGFBR3
Molecular weight: 93,499 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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