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PKG1 an AGC kinase of the PKG family. Type I cGMP-dependent protein kinase; relaxes vascular smooth muscle and inhibits platelet aggregation. Binding of cGMP results in enzyme activation. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKG family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q11.23-q21.1
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: calcium channel regulator activity; cGMP-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; regulation of GTPase activity; signal transduction
Reference #:  Q13976 (UniProtKB)
Alt. Names/Synonyms: cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; KGP1; MGC71944; PGK; PKG; PRKG1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I
Gene Symbols: PRKG1
Molecular weight: 76,364 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
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