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NKCC1 a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q23.3
Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: ammonium transmembrane transporter activity; protein binding; protein kinase binding; sodium:potassium:chloride symporter activity
Biological Process: ammonium transport; ion transport; transepithelial chloride transport; transport
Reference #:  P55011 (UniProtKB)
Alt. Names/Synonyms: Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; MGC104233; NKCC1; S12A2; SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Solute carrier family 12 member 2
Gene Symbols: SLC12A2
Molecular weight: 131,447 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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