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Protein Page:

SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; SCF ubiquitin ligase complex
Molecular Function: identical protein binding; protein binding; ubiquitin-protein ligase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; post-translational protein modification; protein deubiquitination; protein polyubiquitination; regulation of apoptosis
Reference #:  Q13309 (UniProtKB)
Alt. Names/Synonyms: CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL1; FBXL1; FLB1; MGC1366; p45skp2; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); SKP2
Gene Symbols: SKP2
Molecular weight: 47,761 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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