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Protein Page:
HP1 alpha

HP1 alpha Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Interacts with SUV420H1 and SUV420H2. Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: centric heterochromatin; histone deacetylase complex; histone methyltransferase complex; nuclear chromosome, telomeric region; nuclear envelope; nuclear heterochromatin; nucleolus; nucleoplasm; nucleus; PML body; transcriptional repressor complex
Molecular Function: methylated histone residue binding; protein binding; protein binding, bridging
Biological Process: blood coagulation; negative regulation of transcription, DNA-dependent
Reference #:  P45973 (UniProtKB)
Alt. Names/Synonyms: Antigen p25; CBX5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha; HP1-ALPHA; HP1A; HP1Hs alpha
Gene Symbols: CBX5
Molecular weight: 22,225 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HP1 alpha

Protein Structure Not Found.
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