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BRCA2 involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor
Chromosomal Location of Human Ortholog: 13q13.1
Cellular Component: BRCA2-MAGE-D1 complex; centrosome; cytosol; lateral element; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein complex; secretory granule
Molecular Function: gamma-tubulin binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; histone acetyltransferase activity; protease binding; protein binding; protein C-terminus binding; single-stranded DNA binding
Biological Process: centrosome duplication; cytokinesis; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; positive regulation of transcription, DNA-dependent; strand displacement
Disease: Breast Cancer; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Fanconi Anemia, Complementation Group D1; Glioma Susceptibility 3; Medulloblastoma; Pancreatic Cancer, Susceptibility To, 2; Prostate Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Wilms Tumor 1
Reference #:  P51587 (UniProtKB)
Alt. Names/Synonyms: BRCA1/BRCA2-containing complex, subunit 2; BRCA2; BRCC2; breast and ovarian cancer susceptibility gene, early onset; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer susceptibility protein BRCA2; Breast cancer type 2 susceptibility protein; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1; Fanconi anemia group D1 protein; GLM3; PNCA2
Gene Symbols: BRCA2
Molecular weight: 384,202 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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