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IL2RA Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: external side of plasma membrane; integral component of membrane; intracellular; plasma membrane
Molecular Function: drug binding; interleukin-2 binding; interleukin-2 receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: activated T cell apoptosis; apoptosis; cell proliferation; cell surface receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; interleukin-2-mediated signaling pathway; MAPK cascade; negative regulation of defense response to virus; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of T cell proliferation; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; regulation of molecular function; regulation of regulatory T cell differentiation; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction
Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of
Reference #:  P01589 (UniProtKB)
Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
Gene Symbols: IL2RA
Molecular weight: 30,819 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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