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ABCB1 Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 7q21.12
Cellular Component: apical plasma membrane; cell surface; membrane; plasma membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; protein binding; transporter activity; xenobiotic-transporting ATPase activity
Biological Process: G2/M transition of mitotic cell cycle; phospholipid translocation; regulation of response to osmotic stress; response to drug; transmembrane transport; transport
Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
Reference #:  P08183 (UniProtKB)
Alt. Names/Synonyms: ABC20; ABCB1; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1
Gene Symbols: ABCB1
Molecular weight: 141,479 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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