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CTBP1 Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)- specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cytosol; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; NAD binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; transcription factor binding
Biological Process: negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone deacetylation; protein amino acid phosphorylation; regulation of cell cycle; viral genome replication; white fat cell differentiation
Disease: Wolf-hirschhorn Syndrome
Reference #:  Q13363 (UniProtKB)
Alt. Names/Synonyms: BARS; brefeldin A-ribosylated substrate; C-terminal binding protein 1; C-terminal-binding protein 1; CTBP; CTBP1; MGC104684
Gene Symbols: CTBP1
Molecular weight: 47,535 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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