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CDK16 an atypical member of the cyclin-dependent kinase (CDK) family. Activated via binding phosphorylated cyclin Y complexed with 14-3-3 zeta, theta, or eta. Plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Three isoforms of the human protein may be generated via alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/TAIRE subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); TAIRE subfamily
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; microtubule cytoskeleton; nucleus; plasma membrane; synaptic vesicle
Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: exocytosis; growth hormone secretion; neurite development; spermatogenesis
Reference #:  Q00536 (UniProtKB)
Alt. Names/Synonyms: CDK16; Cell division protein kinase 16; cyclin-dependent kinase 16; FLJ16665; PCTAIRE; PCTAIRE-motif protein kinase 1; PCTAIRE1; PCTGAIRE; PCTK1; Serine/threonine-protein kinase PCTAIRE-1
Gene Symbols: CDK16
Molecular weight: 55,716 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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