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PAK6 a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Nuclear receptor co-regulator; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: cell junction; cytoplasm; fibrillar center; nucleus
Molecular Function: cadherin binding; protein binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; apoptosis; cell migration; cytoskeleton organization and biogenesis; regulation of apoptosis; regulation of MAPKKK cascade; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; Rho protein signal transduction; stress-activated protein kinase signaling pathway
Reference #:  Q9NQU5 (UniProtKB)
Alt. Names/Synonyms: p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; PAK5; PAK6; Serine/threonine-protein kinase PAK 6
Gene Symbols: PAK6
Molecular weight: 74,869 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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