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PAK5 a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 20p12.2
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: protein binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase activity; apoptosis; cell growth; cell migration; cell proliferation; cytoskeleton organization and biogenesis; regulation of apoptosis; regulation of MAPKKK cascade; regulation of mitotic cell cycle; Rho protein signal transduction; signal transduction; stress-activated protein kinase signaling pathway
Reference #:  Q9P286 (UniProtKB)
Alt. Names/Synonyms: KIAA1264; MGC26232; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-5; PAK-7; PAK5; PAK7; protein kinase PAK5; Serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7
Gene Symbols: PAK7
Molecular weight: 80,745 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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