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mGluR2 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 9|9 F1
Cellular Component: axon; integral to plasma membrane; intracellular; neuron projection; presynaptic membrane
Molecular Function: calcium channel regulator activity; group II metabotropic glutamate receptor activity
Biological Process: glutamate secretion; regulation of synaptic transmission, glutamatergic; synaptic transmission
Reference #:  Q14BI2 (UniProtKB)
Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGluR2; mGluR7
Gene Symbols: Grm2
Molecular weight: 95,887 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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