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RAB3A Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: axon; cytosol; plasma membrane; secretory granule membrane; synaptic vesicle; terminal button
Molecular Function: GTPase activity; myosin V binding; protein binding
Biological Process: constitutive secretory pathway; glutamate secretion; neurotransmitter secretion; neutrophil degranulation; positive regulation of exocytosis; post-translational protein modification; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle exocytosis
Reference #:  P20336 (UniProtKB)
Alt. Names/Synonyms: RAB3A; RAB3A, member RAS oncogene family; RAS-associated protein RAB3A; Ras-related protein Rab-3A
Gene Symbols: RAB3A
Molecular weight: 24,984 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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