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FAS Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: CD95 death-inducing signaling complex; cell surface; cytosol; extracellular exosome; integral component of plasma membrane; membrane raft; mitochondrion; nuclear body; plasma membrane
Molecular Function: calmodulin binding; identical protein binding; kinase binding; protein binding; receptor activity; signal transducer activity; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptosis; cellular response to amino acid starvation; cellular response to hyperoxia; immune response; inflammatory response; multicellular organism development; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of protein phosphorylation; protein complex assembly; regulation of apoptosis; regulation of cell proliferation; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of stress-activated MAPK cascade; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Disease: Autoimmune Lymphoproliferative Syndrome
Reference #:  P25445 (UniProtKB)
Alt. Names/Synonyms: ALPS1A; APO-1; Apo-1 antigen; APO-1 cell surface antigen; apoptosis antigen 1; Apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; FAS1; FASLG receptor; FASTM; TNFRSF6; TNR6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
Gene Symbols: FAS
Molecular weight: 37,732 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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