Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine
Molecular Function: calmodulin binding; identical protein binding; kinase binding; protein binding; receptor activity; signal transducer activity; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptosis; cellular response to amino acid starvation; cellular response to hyperoxia; immune response; inflammatory response; multicellular organism development; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of protein phosphorylation; protein complex assembly; regulation of apoptosis; regulation of cell proliferation; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of stress-activated MAPK cascade; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway